The Birth of a Monocyte: Inflammatory Language No. 4

Monocyte by Asthydays 2012
Having only three days to live would be…daunting. I don’t suppose monocytes consider this, but once they enter the circulation, they have three days to either participate in inflammatory response reactions (be a reactionary) or die an oxidative death, only to be replaced by the next “frantic” monocyte. And so goes their life cycle.

Long before a monocyte is “born,” its ancestor or progenitor, a pluripotent stem cell, lives within bone marrow stromal cells and is capable of turning into any other kind of human cell: heart cell, liver cell, or a cell of the blood, to name a few. Some pluripotent stem cells develop into hematopoetic stem cells (HSC) that further develop into the blood cells of the human body—the lymphoid or myeloid cell lines. The myeloid cell line encompasses the platelets, red blood cells, mast cells, basophils, neutrophils, and eosinophils. It also encompasses monocytes, macrophages, and myeloid dendritic cells, leading to the birth of potential reactionaries.


From Wikipedia

In 1915, the movie The Birth of a Nation was released, triggering inflammatory responses all over the United States. Additionally, it became a recruitment tool for the KKK. The dangerous and faulty parallel between that movie and the monocyte is this: the monocyte can lead to inflammatory reactions, and the monocyte can recruit immune or reactionary cells. The parallel breaks down when there is no need to react, that it would be wrong and disease-causing to do so; so the tolerant monocyte just hangs out. There is no inflammation via its doing.

In the human, the majority of new monocytes are produced in the bone marrow of the vertebrae or sternum. In fetuses less than 4-5 months gestation, they are produced in the spleen and liver. Within a niche, a particular microenvironment of the bone marrow not yet determined, HSCs develop. This niche could be an osteoblastic (cell that builds bone) niche, an endothelial cell (lining of blood vessel) niche, a multipotent primitive mesenchymal cell (like CAR and nestin-expressing) niche in the stromal cells, or a combination of some or all of these.

From Wikipedia
Although the exact niche for HSC isn’t known, studies have revealed that CXCL12-CXCR4 (ligand-receptor) signaling is necessary for maintenance of HSC and their progenies. And, by influence of certain chemokines like interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony stimulating factor (GM-CSF), and stem cell factor (SCF), the myeloid cell line develops.

GM-CSF causes further differentiation (specialization) of the myeloid to a myeloblast, which is further differentiated into basophils, neutrophils, eosinophils, and monocytes. SCF, GM-CSF, IL-3 and IL-6, and specifically M-CSF aid in the development of promonoblasts, monoblasts, promonocytes, then finally—monocytes.

Macrophage: First Attempt by The Sensitive Scientist 2011 
The monocytes can reside within the marrow, be stored in the spleen, or nonchalantly patrol the blood for microbes—and await activation into macrophages or dendritic cells. If unchanged, the monocytes eventually die an apoptotic death. Their lack of DNA repair genes may have something to do with this for macrophages or dendritic cells are able to repair their DNA, and therefore live longer. I don’t suppose a monocyte considers this either, but it is their life.

Sources:

Apoptosis of monocyte: Bauer M, Goldstein M, Heylmann D, Kaina B (2012) Human Monocytes Undergo Excessive Apoptosis following Temozolomide Activating the ATM/ATR Pathway While Dendritic Cells and Macrophages Are Resistant. PLoS ONE 7(6): e39956. doi:10.1371/journal.pone.0039956

Bone marrow niches for HSC: Sugiyama T, NagasawaT ; Inf lamm Allergy Drug Targets. 2012 June; 11(3): 201–206. Published online 2012 June. doi:  10.2174/187152812800392689


There will be three Inflammatory Language posts devoted to monocytes. The first of which, Monocyte Fashion, addressed the style or types of monocytes. This post is the second devoted to monocytes. The third and forthcoming post will address cell trafficking, from the monocyte’s perspective. Future posts will eventually address the rest of Inflammatory Language, the song.

This is the fourth post of a series: Inflammatory Language. The series will briefly emphasize aspects of inflammation, mainly in response to microorganisms, but not always. You can contribute to this column by submitting a 300-500 word piece (or artwork) to me by email, along with byline. If deemed appropriate (it can be serious, political, scientific, or funny as long as it pertains to inflammation), we'll publish it here and the first place post (deadline February 28, 2013) will receive one copy of The Best Science Writing Online 2012 published by Scientific American/FSG!

Comments

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    Replies
    1. Hello everyone am BRIAN WALKER,
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    ReplyDelete
    Replies
    1. Hello everyone am BRIAN WALKER,
      From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
      Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
      for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

      DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
      Permanent penis enlargement
      Thick penis
      Bigger penis head
      Effective erections
      HIV
      ALS
      HERPES
      CANCER
      Best regard
      BRIAN WALKER.

      Delete
  7. Many people wonder if there is a natural cure for Hiv or are looking for ways on how to get rid of Hiv for good. there are many natural Hiv remedies that can put Hiv into remission. there is a method for how to get rid of Hiv Which is taking of herbal medicines. My problem with Hiv has caused me many traumas,especially in my sex life.I was so afraid of infecting my girlfriend, I suffered the embarrassment of visiting dermatologists queries hundreds of times.Unfortunately, they did not find a definitive solution to my problem.The solution came from the least expected herbal doctor which is Dr idahosa. By reading in a specialized forum on the subject,How to cure Hiv virus completely. Many people had tried, with excellent and quick results.I had nothing to lose so I decided to contact dr. idahosa and use his herbal medicine to eliminate my Hiv. I spent three weeks using his herbal medicine and today my Hiv completely disappeared and turn out negative after numerous test from different hospitals. I recommend this method to all people who want to eliminate the Hiv from their body forever, The doctor contact,{ dridahosasolutioncenter@gmail.com }or Call His Whatsapp Number:+2348134261542

    ReplyDelete
  8. My life is beautiful thanks to you, Mein Helfer. Lord Jesus in my life as a candle light in the darkness. You showed me the meaning of faith with your words. I know that even when I cried all day thinking about how to recover, you were not sleeping, you were dear to me. I contacted the herbal center Dr Itua, who lived in West Africa. A friend of mine here in Hamburg is also from Africa. She told me about African herbs but I was nervous. I am very afraid when it comes to Africa because I heard many terrible things about them because of my Christianity. god for direction, take a bold step and get in touch with him in the email and then move to WhatsApp, he asked me if I can come for treatment or I want a delivery, I told him I wanted to know him I buy ticket in 2 ways to Africa To meet Dr. Itua, I went there and I was speechless from the people I saw there. Patent, sick people. Itua is a god sent to the world, I told my pastor about what I am doing, Pastor Bill Scheer. We have a real battle beautifully with Spirit and Flesh. Adoration that same night. He prayed for me and asked me to lead. I spent 2 weeks and 2 days in Africa at Dr Itua Herbal Home. After the treatment, he asked me to meet his nurse for the HIV test when I did it. It was negative, I asked my friend to take me to another nearby hospital when I arrived, it was negative. I was overwhite with the result, but happy inside of me. We went with Dr. Itua, I thank him but I explain that I do not have enough to show him my appreciation, that he understands my situation, but I promise that he will testify about his good work. Thank God for my dear friend, Emma, I know I could be reading this now, I want to thank you. And many thanks to Dr. Itua Herbal Center. He gave me his calendar that I put on my wall in my house. Dr. Itua can also cure the following diseases ... Cancer, HIV, Herpes, Hepatitis B, Inflammatory Liver, Diabetis, Fribroid,Parkinson's disease,Inflammatory bowel disease ,Fibromyalgia, recover your ex. You can contact him by email or whatsapp, @ .. drituaherbalcenter@gmail.com, phone number .. + 2348149277967 .. He is a good doctor, talk to him kindly. I'm sure he will also listen to you.

    ReplyDelete
  9. I can’t believe this. A great testimony that i must share to all HERPES patient in the world i never believed that their could be any complete cure for HERPES or any cure for HERPES,i saw people’s testimony on sites of how DR OLU prepare herbal cure and brought them back to life again. i had to try it too and you can,t believe that in just few weeks i started using it all my pains stop gradually and i had to leave without the HERPES DRUGS the doctor gave to me. Right now i can tell you that few months now i have not had any pain,delay in treatment leads to death. Here is his email:drolusolutionhome@gmail.com his WHATSAPP number is +2348040654426

    ReplyDelete
  10. I am Tamara Paytan, When I eventually found testimonies about this spell caster Dr Isikolo, how he helped many people to get their lovers and broken homes back, i contacted him through his email address isikolosolutionhome@gmail.com because I was absolutely desperate to get my wife back. Life without my wife was a real mess for me and my children. i wanted a dramatic change and I thought magic could be the solution. After discussing the resolution with Dr imesagbor, he gave me hope that he will restore my marriage. I felt confident that he will actually make my wife to return home and he did! It’s fantastic what this great spellcaster have done for me, his help is priceless! I don't know what I would have done without Dr Isikolo, Dr imesagbor does his job so well he is organized and highly functional, i believe he is the best spell caster i can count on when it comes to all kinds of spell, I was floored that his spells worked, if you need help, contact him on isikolosolutionhome@gmail.com. call or Whatsapp him on +2348133261196 and i assure you things will turn around for you

    ReplyDelete
  11. Replies
    1. Hello everyone am BRIAN WALKER,
      From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
      Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
      for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

      DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
      Permanent penis enlargement
      Thick penis
      Bigger penis head
      Effective erections
      HIV
      ALS
      HERPES
      CANCER
      Best regard
      BRIAN WALKER.

      Delete
  12. I can’t believe this is really true I never believe there is cure to this hsv 2 because all the hospital have told me there is no cure to it, few months ago I saw this man email DR.AZIEGBE on internet from a testimony share by someone who he help with his herbal cure I contact his email and ask for his help also, that is how he inform me about the cure process and this man sent me a herbal medicine which I took according to the way he instructed for 2 week I can’t believe when I go for test my result come out negative i am so happy to share this to the world there is real cure to herpes you can also contact DR.AZIEGBE through his email now DRAZIEGBE1SPELLHOME@GMAIL.COM and also WhatsApp him +2349035465208. or my assistant text me +1 (601) 452-8622 or email: JAMESAVA0001@GMAIL.COM...

    ReplyDelete
  13. Hello viewers around the Globe, I was despondent because i had a very small penis, about 2.5 inches soft and 4 inches hard not nice enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr, OMOHAN and i decided to contact him on his EMAIL i saw on the internethttp:/{dromohanherbalmedicine@gmail.com} so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Ella, i was surprised when she said that she is satisfied with my sex and i have got a large penis. Am so happy, thanks to Dr OMOHAN I also learn that Dr OMOHAN also help with Breast Enlargement Hips and Bums Enlargement etc.. If you are in any situation with a little Penis, weak ejaculation, small breast_hips_bums do get to Dr OMOHAN now for help on his email {dromohanherbalmedicine@gmail.com} or whats app him number: +2348164816038}

    ReplyDelete
  14. Hello everyone am BRIAN WALKER,
    From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
    Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
    for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

    DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
    Permanent penis enlargement
    Thick penis
    Bigger penis head
    Effective erections
    HIV
    ALS
    HERPES
    CANCER
    Best regard
    BRIAN WALKER.

    ReplyDelete
  15. Hiv disease for the last 3 years and had pain hard to eat and cough are nightmares,especially the first year At this stage, the immune system is severely weakened, and the risk of contracting opportunistic infections is much greater. However, not everyone with HIV will go on to develop AIDS. The earlier you receive treatment, the better your outcome will be.I started taking ARV to avoid early death but I had faith in God that i would be healed someday.As a Hiv patent we are advise to be taking antiretroviral treatments to reduce our chance of transmitting the virus to others , few weeks ago i came on search on the internet if i could get any information on Hiv treatment with herbal medicine, on my search i saw a testimony of someone who has been healed from Hiv her name was Achima Abelard and other Herpes Virus patent Tasha Moore also giving testimony about this same man,Called Dr Itua Herbal Center.I was moved by the testimony and i contacted him by his Email.drituaherbalcenter@gmail.com We chatted and he send me a bottle of herbal medicine I drank it as he instructed me to.After drinking it he ask me to go for a test that how i ended my suffering life of Hiv patent,I'm cured and free of Arv Pills.I'm forever grateful to him Drituaherbalcenter.Here his contact Number +2348149277967...He assure me he can cure the following disease..Hiv,Cancer,Herpes Virus,Lyme Disease,Epilepsy, ,Bladder Cancer,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Non Hodgkin Lymphoma,Skin Cancer,Uterine Cancer,Prostate Cancer, fibromyalgia ,ALS,Hepatitis,Copd,Parkinson disease.Genetic disease,Fibrodysplasia disease,Fibrodysplasia Ossificans Progressiva,Fluoroquinolone Toxicity Syndrome,Inflammatory bowel disease ,Huntington's disease ,Diabetes,Fibroid...

    ReplyDelete
    Replies
    1. My name is Benita Willson from GERMANY, I want to quickly tell the world that there is a real spell caster that is powerful and genuine, His name is Dr Ken He helped me recently to reunite my relationship with my husband who left me, When i contacted Dr Ken he cast a love spell for me and my husband who said he doesn't have anything to do with me again called me and started begging me. he is back now with so much love and care. today i am glad to let you all know that this spell caster have the powers to bring lovers back. because i am now happy with my husband. To anyone who is reading this article and needs any help, Dr Ken can help...You can contact him Via this email greatdrkenspelltemple@gmail.com or via WhatsApp with this number +2348104557346


      My name is Benita Willson from GERMANY, I want to quickly tell the world that there is a real spell caster that is powerful and genuine, His name is Dr Ken He helped me recently to reunite my relationship with my husband who left me, When i contacted Dr Ken he cast a love spell for me and my husband who said he doesn't have anything to do with me again called me and started begging me. he is back now with so much love and care. today i am glad to let you all know that this spell caster have the powers to bring lovers back. because i am now happy with my husband. To anyone who is reading this article and needs any help, Dr Ken can help...You can contact him Via this email greatdrkenspelltemple@gmail.com or via WhatsApp with this number +2348104557346

      Delete
  16. I was diagnosed of herpes virus in 2015, I have tried all possible means to get cure but all my effort proved abortive, until a friend of mine introduced me to a herbal doctor called dr. Azuka, who prepare herbal medicine to cure all kind of diseases including herpes virus (Herpes), when i contacted this herbal doctor via his email (dr.azukasolutionhome@gmail.com), he sent me herpes virus herbal medicine via courier service, when i received the herbal medicine he gave me step by step instructions on how to apply it, when i applied it as instructed i was totally cured from the virus within 3 weeks of usage. Contact this great herbal doctor via (dr.azukasolutionhome@gmail.com) or whatsApp +2348132777335 him today to get your cure.

    ReplyDelete
  17. I want to testify of how i got cured from HIV By Dr Omolowa, I have been living with this disease for the past 11months, i have done all i can to cure this disease but all my efforts proved abortive until i met an old friend of mine who told me about a herbalist from Africa who cures several types of diseases such as hepatitis A B and C, Human Papillomavirus (HPV),Herpes and so many more. though i have doubt about it,I decided to give it a try when i contacted this herbalist,he helped me cast a healing spell and send me a herbal medicine which i make use of according to his instructions and now behold the HIV is gone and i now have my life back,If you are out there living with this disease i will like you to get cure today by Contacting this great herbalist on his email:dr.omolowa@gmail.com WhatsApp: +2349039377739 Good luck and God bles

    ReplyDelete
  18. I will like to share this great testimony of buba.herbalmiraclemedicine@gmail.com or website https://bubaherbalmiraclemedicine.wordpress.com/ that helped me to save my marriage by increasing my Penis size and i now know that penis size really matters in a relationship or marriage. I got married to my wife about 2 month after we met on a photo studio, we lived happily for the first 5 months of our marriage until i and my wife start having quarrels at home because i couldn't satisfy her on bed with my small penis. Actually my penis was very small, it measured about 3.5 inch long on erection and i am 35 years old ,man. My wife said it was forbidden by the women of this world.. Sometimes i will return from work without finding my wife at home and whenever i call or ask her where she was, she will always snub at me and sometimes just tell me to go get a larger dick. All this continued for a long time and it hurt me so much that i was at the edge of breaking up on the marriage till when i read about a Herbal doctor called DR. MOSES BUBA online. I never thought i could smile and be in a happy marriage again if not for the help of DR MOSES BUBA I got the DR MOSES BUBA on his Emails: buba.herbalmiraclemedicine@gmail.com on the internet and i emailed him, and he got back to me with some encouraging words, he got me some herbal cream which i use for just 7 days and i began to feel the enlargement of my penis, and without surgery. This went on for a little period of about 10 days and to my greatest surprise my wife keeps screaming that she love my big dick now. Now my wife no longer fight with me, and my penis is now about 11.5 inches long on erection and off course very large round. And now my wife uses breasts, hips and bums enlargement. I and my wife are very happy for the help rendered to me by DR.MOSES BUBA, and i want to say a big thanks to DR MOSES BUBA for the help. You can contact DR MOSES BUBA on his Email: buba.herbalmiraclemedicine@gmail.com or visit his website https://bubaherbalmiraclemedicine.wordpress.com/
    i am so thankful to DR MOSES BUBA for helping me. you can call OR whatsapp him +2348128712230

    ReplyDelete

  19. I was in trouble when my doctor told me that i have been diagnosed with
    herpes and i know my family will face a serious problem . when i am gone i
    lost hope and wept most of the time, but one day i was surfing the internet
    i saw Dr. omohan herbal home contact number online i called him and he
    guided me. i asked him for solutions and he started the remedy for my
    health thank God,now everything is fine i am cured by Dr. omohan herbal
    medicine am very thankful to Dr. omohan and very happy with my hobby and
    family email him on (dromohanherbalmedicine@gmail.com) call/whatsapp number +2348164816038

    He can as well cure the following disease;

    Herpes,
    Asthma,
    Cancer,
    HSV1, &
    HSV2,
    Hepatitis B,
    HIV/AID ETC.

    ReplyDelete
  20. I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive or any STD diseases his email is: drisiborspellhome@gmail.com or you can call or whatsApp his mobile number on +2348107855231.

    ReplyDelete

  21. I would like to let all know that the size of your Penis really matters in your relationship or marriage. I got married to my wife about 1 month after we met on a photo studio, we lived happily for the first 3 months of our marriage until i and my wife started having quarrels at home because i couldn't satisfy her on bed with my little penis. Actually my penis was very small, it measured about 4.5 inch long on erection and i am 39 years old. My wife said it was forbidden by the women of this world. My wife started sleeping with other men outside. Sometimes i will return from work without finding my wife at home and whenever i call or ask her where she was, she will always snub at me and sometimes just tell me to go get a larger dick. All this continued for a long time and it hurt me so much that i was at the edge of breaking up on the marriage till when i read about a doctor called DR.OMOHAN. online. I never thought i could smile and be in a happy marriage again if not for the help of DR.OMOHAN. I got the doctors Emails:(dromohanherbalmedicine@gmail.com ) on the internet and i emailed him, and he got back to me with some encouraging words, he got me some herbs cream which i use for just 8 days and i began to feel the enlargement of my penis, and without surgery. This went on for a little period of about 10 days and to my surprise my wife keeps screaming that she love my big dick now. Now my wife no longer cheat on me, and my penis is now about 10.5 inches long on erection and off course very large round. And now my wife uses breasts, hips and bums enlargement. I and my wife are very happy for the help rendered to me by DR.OMOHAN , and i want to say a big thanks to Doctor for the help. You can contact the Doctor now on his Email:( dromohanherbalmedicine@gmail.com ) Am thankful to the doctor for helping me.
    his whataspp number +2348164816038

    DOCTOR OMOHAN CAN AS WELL HELP THE FOLLOWING PROBLEMS
    1. HIV/AIDS SPELL
    2. HERPES SPELL
    3. CANCER SPELL
    4 IF YOU WANT YOUR EX LOVER BACK SPELL
    5 IF YOU NEED A BABY SPELLhim to solve
    6 LOW SPERM COUNT SPELL
    get all your problem solve. No problem is too big for him to solve.

    ReplyDelete
  22. Thanks to great Dr.Aire I’m Laura Ben from California. i was an HIV victim. i had it for over four years i do visit hospital always before. I was just at the point of death with shame after i have lost everything in life even my love one until my close relative direct me to this site to look for great Dr.Aire . It so amazing to see my self back to my feet with every thing i have lost. i am very happy because Dr.Aire did not only cure my sickness but he restructure my life by bringing back my ex and every thing i lost to the course of this sickness(HIV). i do not really know where to start from in appreciating you Dr.Aire . please my people out there do not play with your problem go out and seeks for the help of great Dr .Aire herbal healing, he healed me without future problem or hidden charges. now i am free from HPV and My husband, my joy and happiness are back. please with out a second choice go contact great Dr.Aire for the betterment of your life. CONTACT HIM VIA EMAIL; drairehome@gmail.com ;or whatsapp number +2347036740271

    ReplyDelete
  23. Readers,be careful here nobody can help you here or even suggest how you can get your ex or love back,most testimonies of most spell casters here must be ignored.because most of them are scam i mean real scam which i was a victim and i got ripped of thousands of dollars because i was so anxious to get my lover back after she left me for over 2 years and 7 months with my 6 years old daughter,i have applied to more than 4 different spell casters here and all to no avail they all ask for same thing send your name your ex,address,picture phone number etc which i did over and over again and most of them were from west Africa until i saw a post about GREAT DR KEN and i decided to give him my last trial.he ask me for 4 things which are my real name,my ex and my ex mother name and some little amount of money to get some items and said my ex will come back in 3days, i have paid over $3500 on spell casting and nothing have work for me after 3days i was thinking about how much i have lost so far so i said let me give him a try so i called him again and send my real name,my ex and my ex mother name and the money for items he requested for because i swear it was my last try so i was waiting as he told me to wait till the next 3 days and i could not sleep those night because i really love my wife and want her back at 9pm the third day i saw my wife online on facebook and she said hi at first i was shocked because she never talked with me for the past 2years and 7 month now i did not reply again she said are you there? i quickly reply yes and she said can we see tomorrow i said yes and she went off-line i was confused i try to chat her up again but she was no more online i could not sleep that night as i was wondering what she is going to say, by 7.am the next morning she gave me a miss call i decided not to call back as i was still in shock again she called and i pick she said can we see after work today i said yes so she ended the call immediately i got off work he called me and we met and all she deed was to beg me to take her and our daughter back.I had no choice than to take her back because i love her so much and now we are back again i called THE GREAT DR KEN that same day to thank him for what he has done infact i still call him and thank him as my life was not complete without my wife please be careful here i have been scammed thousands of dollars if you want a true love spell then contact GREAT DR KEN on his email address greatdrkenspelltemple@gmail.com or whatsapp him via his phone number +2348104557346.

    ReplyDelete
  24. I want to tell about how i was cured of HPV by a Doctor called Dr muthuka, I was browsing through the Internet searching for remedy On HPV and i saw comment of people talking about how Dr muthuka cured them. I Was skeptical because i never believed in the Internet but i was convince to give him a try because i had no hope of been cured of HPV, so i decided to contact him with his email that was listed on the Comment muthukaherbalhome@gmil.com when i contacted him he gave me hope and he sent a Herbal medicine to me that i took and it seriously worked for me. You can also contact him if you have any problem.... Email muthukaherbalhome@gmil.com or call and whatsapp this number +2347036143964 or call +2348105817441 okay thank or check on website http://muhuka.blogspot.com

    ReplyDelete
  25. I am here to say a big thank you to my doctor DR OLIHA who helped me enlarge my penis.i have never had a happy relationship in my life because of my inability to perform well due to my small penis, due to frustration,i went online in search of solution to ending my predicament and than i came across testimony on how DR OLIHA has helped them, so i contacted him and he promised to help me with penis enlargement,i doubted at first but i gave him a trial and he sent me the product which i used according to his prescription and in less than a week,i saw changes in my penis and it grow to the size i wanted and since then,i am now a happy man and no lady complains again about my penis.if you also need the services of my doctor,you can also contact him on his email..{oliha.miraclemedicine@gmail.com} or his whataspp is +2349038382931

    ReplyDelete
  26. I Never believed i was ever going to be HIV Negative again,Dr OSAGIE has
    given me reasons to be happy, i was HIV positive for 2years and all the
    means i tried for treatment was not helpful to me, but when i came on
    the Internet i saw great testimony about Dr OSAGIE on how he was able to
    cure someone from HIV, this person said great things about this man, and
    advice we contact him for any Disease problem that Dr OSAGIE can be of
    help, well i decided to give him a try, he requested for my information
    which i sent to him, and he told me he was going to prepare for me a
    healing portion, which he wanted me to take for days, and after which i
    should go back to the hospital for check up, well after taking all the
    treatment sent to me by Dr OSAGIE, i went back to the Hospital for check
    up, and now i have been confirmed HIV Negative, friends you can reach Dr
    DR OSAGIE on any treatment for any Disease he is the one only i can show
    you all up to, reach
    DROSAGIESOULTIONTEMPLE@YAHOO.COM)
    or join him on whatapps /call with this is +234768398092 or his is number call
    +2347068398092

    ReplyDelete
  27. I Never believed i was ever going to be HIV Negative again,Dr OSAGIE has
    given me reasons to be happy, i was HIV positive for 2years and all the
    means i tried for treatment was not helpful to me, but when i came on
    the Internet i saw great testimony about Dr OSAGIE on how he was able to
    cure someone from HIV, this person said great things about this man, and
    advice we contact him for any Disease problem that Dr OSAGIE can be of
    help, well i decided to give him a try, he requested for my information
    which i sent to him, and he told me he was going to prepare for me a
    healing portion, which he wanted me to take for days, and after which i
    should go back to the hospital for check up, well after taking all the
    treatment sent to me by Dr OSAGIE, i went back to the Hospital for check
    up, and now i have been confirmed HIV Negative, friends you can reach Dr
    DR OSAGIE on any treatment for any Disease he is the one only i can show
    you all up to, reach
    DROSAGIESOULTIONTEMPLE@YAHOO.COM)
    or join him on whatapps /call with this is +234768398092 or his is number call
    +2347068398092

    ReplyDelete
  28. My name is Mira Emma , i am from New York City. I was suffering from HIV disease for over 4 years, i was hopeless until one of my friend directed me to a man called Dr Udi, she said he cures the sickness and also said he has also helped her friend, i never believed her but after alot of talk, i decided to give him a try, just few days ago i contacted him and he told me what to do which i did and he cast a spell for me and told me to go for a test which i also did and when the result came out i was surprised to see that i am negative. I am proud to tell you the i am the most happiest person on earth I Give thanks to Dr Udi.. If you are having any problem and you need help, You can contact him with his email drudiherbalhome@gmail.com or Whatapp: +2348051243538.

    ReplyDelete
  29. My name is Benita Willson from GERMANY, I want to quickly tell the world that there is a real spell caster that is powerful and genuine, His name is Dr Ken He helped me recently to reunite my relationship with my husband who left me, When i contacted Dr Ken he cast a love spell for me and my husband who said he doesn't have anything to do with me again called me and started begging me. he is back now with so much love and care. today i am glad to let you all know that this spell caster have the powers to bring lovers back. because i am now happy with my husband. To anyone who is reading this article and needs any help, Dr Ken can help...You can contact him Via this email greatdrkenspelltemple@gmail.com or via WhatsApp with this number +2348104557346


    My name is Benita Willson from GERMANY, I want to quickly tell the world that there is a real spell caster that is powerful and genuine, His name is Dr Ken He helped me recently to reunite my relationship with my husband who left me, When i contacted Dr Ken he cast a love spell for me and my husband who said he doesn't have anything to do with me again called me and started begging me. he is back now with so much love and care. today i am glad to let you all know that this spell caster have the powers to bring lovers back. because i am now happy with my husband. To anyone who is reading this article and needs any help, Dr Ken can help...You can contact him Via this email greatdrkenspelltemple@gmail.com or via WhatsApp with this number +2348104557346

    ReplyDelete
  30. Hello everyone i am HELEN JACK from USA i want to tell the word of a great man who help me cure my HIV I was once suffering from HIV and i spent a lot of money contacting
    several doctors all round the world for cure but no avail until i came
    in contact with this powerful Man called Dr.ovoko who cured me from
    HIV with his Powerful herbal medication, He sent the Herbs to me via
    D.H.L and i got it in just 2 days and i followed his prescription on
    how to use the herbal medicine and it worked perfectly. Now i am HIV
    Negative when i did a test in the hospital, Dont doubt it. please if
    you are contacted with any form of Deadly Diseases.
    Contact Dr.ovoko on his mail Drovokospelltemple77@gmail.com
    And his Direct whatsapp number +2347063915230 THANK YOU FOR READING

    ReplyDelete
  31. Grateful to DR UDI for all his help for my life, my partner was having Herpes Simplex Virus, and we were planing on getting married, when we decided to get ourselves tested first and we found out that my Girlfriend was HSV 2 Positive, my Girlfriend was so unhappy, because this was a barrier for us to get married, so i went out to search out a remedy for my partner, and it was so surprising how DR UDI has been a blessing and healing to the masses, after reading about his work on a blog i immediately emailed him: [Drudiherbalhome@gmail .com] and he wrote back to me that my Girlfriend will be OK and that we we get married this same year, i couldn't believe it, after doing all that is needed to be done, i was surprise that after 2weeks of using his medicine my Girlfriend went to the doc and was diagnose negative. For more info contact his email (drudiherbalhome@gmail .com) or call or what-app him via +2348051243538 and you will get your illness cure.

    ReplyDelete
  32. I was depressed when doctor told me that I have been diagnosed with Herpes disease… I thought about my Family, I know my Family will face a serious problem when I'm gone, I lost hope and I wept all day, but one day I was searching the internet I found Dr.ezomo contact number. +2349069171173 I called him and he guided me. I asked him for solutions and he started the remedies for my health. Thank God, now everything is fine, I'm cured by Dr.ezomo herbal medicine, I'm very thankful to Dr.ezomo and very happy with my hubby and family. email him on dr.ezomorootandherbals@gmail.com or you can also reach him through WhatsApp number+2349069171173 He can also cure so many sickness {1}HIV And AIDS {2}Diabetes {3}Epilepsy {4}Blood Cancer {5}HPV {7}ALS {8}Hepatitis

    ReplyDelete
  33. My name is David Richardson from USA I want to share a testimony of how Dr Perfect herbal mixture cream saved me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing and I was also having weak erection problem. I can't make love to my wife and my penis was just too small, a full grown man like me having 3 inches penis and to worsen it I don't last long in sex I can't even last four minutes it was really a big shame to me. My wife was really tired of me because my sex life was very poor, she never enjoyed sex, I was always thinking and searching for solutions everywhere until when I saw a testimony of how Dr Perfect herbal mixture cream have been helping people regarding their sex life, so I decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 10 inches I couldn't believe my eyes and as I speak now my penis is now 10 inches long and I don't have weak erection anymore. I can make love to my wife longer in bed. And my marriage is now stable my wife is now enjoy me very well in bed. All thanks to Dr Perfect for enlarging my penis he indeed save my marriage. You can contact him at solutiontoallproblems1@gmail.com or you can add him up on WhatsApp +1(256) 251 3614. He also specializes in the following things
    Herpes virus
    Cancer
    Hsv
    Chronic venous disease
    and others

    ReplyDelete
  34. All thanks to Dr Alli for curing my herpes virus/hpv with his herbal medicine, i do not have much to say but with all my life i will forever be grateful to him and God Almighty for using Dr Alli to reach me when i thought it was all over, today i am happy with my life again after the medical doctor have confirmed my HERPES SIMPLEX VIRUS / HPV of 5 is gone,i have never in my life believed that HERPES SIMPLEX VIRUS could be cured by herbal medicine. so i want to use this means to reach other persons who have this disease by testifying the power of Dr Alli that all hope is not lost yet, try and contact him by any means for any kind of disease with his email: ( Allispellhelp1@gmail.com ) or his whatsapp number +2348100772528 and get your healing

    ReplyDelete
  35. HOW DR PERFECT ENLARGEMENT CREAM HELP ME TO ENLARGE MY PENIS YOU CAN ADD HIM UP ON WHATSAPP +1(256) 251 3614

    My name is David Richardson from USA I want to share a testimony of how Dr Perfect herbal mixture cream saved me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing and I was also having weak erection problem. I can't make love to my wife and my penis was just too small, a full grown man like me having 3 inches penis and to worsen it I don't last long in sex I can't even last four minutes it was really a big shame to me. My wife was really tired of me because my sex life was very poor, she never enjoyed sex, I was always thinking and searching for solutions everywhere until when I saw a testimony of how Dr Perfect herbal mixture cream have been helping people regarding their sex life, so I decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 10 inches I couldn't believe my eyes and as I speak now my penis is now 10 inches long and I don't have weak erection anymore. I can make love to my wife longer in bed. And my marriage is now stable my wife is now enjoy me very well in bed. All thanks to Dr Perfect for enlarging my penis he indeed save my marriage. You can contact him at solutiontoallproblems1@gmail.com or you can add him up on WhatsApp +1(256) 251 3614. He also specializes in the following things
    Herpes virus
    Cancer
    Hsv
    Chronic venous disease
    and others

    ReplyDelete
  36. I am John Danilla from UK( northern ireland), i want to share a
    testimony on how a powerful spell caster cured my HIV disease, i was
    diagnosed of this disease, in the year 2009, last week i saw a testimony on
    Dr.Akioya on how he cured an HIV patient, so i contacted him through phone
    call and he asked me to email him, which idid, so he told me that all my
    problems is over and then he decided to do an healing spell spell for me so
    after he finished it, he told me to wait for just 24 hours and then i
    should go for a test, so i really did as he had said, so my greatest
    surprised when i went to the hospital to go for an HIV test, the Medical
    doctor diagnosed that, i am now HIV negetative at first i was amazed and
    now i have come to realise that this spell caster Dr. Akioya is a very
    powerful one and a real spell caster. So viewers of this should please join
    me in my celebration for i am the happiest man on earth today and if you
    want to contact him, you can do this via his email
    (drakioya17spellhome@gmail.com or call him or whatsapp him
    +2348105257464.

    ReplyDelete

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